Handball starts with a throw-off. The team which starts the game is chosen with a simple coin toss, similar to other sports such as football or soccer. With no exceptions, a handball game always starts in the middle of the 40m court.
A throw off is also how the game resumes after each scored goal. As at the beginning of the game, it only takes one player for the throw-off to a teammate. Throw offs can be played in any direction, as long as they start in the middle of the court.